{"product_id":"kisspeptin-5mg","title":"Kisspeptin 5mg – HPG Axis Research Peptide | Tides Lab","description":"\u003cp\u003e \u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eKisspeptin is an endogenous neuropeptide encoded by the KISS1 gene, recognised as a critical upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It has been extensively studied in reproductive endocrinology research, with particular focus on its role in gonadotropin-releasing hormone (GnRH) signalling and the central regulation of reproductive function.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThis 5mg lyophilised formulation is supplied at ≥99% purity and intended strictly for laboratory research purposes.\u003c\/p\u003e\n\u003ch2 class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eKey Features\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e5mg lyophilised Kisspeptin\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eEndogenous KISS1-derived neuropeptide studied in HPG axis research\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eKey upstream regulator of GnRH signalling in neuroendocrine models\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e≥99% purity\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eResearch use only\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eFast Australian shipping\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eMechanism Overview\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eKisspeptin exerts its primary studied effects through binding to the kisspeptin receptor (KISS1R, also known as GPR54), a G protein-coupled receptor expressed on GnRH-secreting neurons in the hypothalamus. In research models, activation of KISS1R by kisspeptin has been consistently described as stimulating pulsatile GnRH release from hypothalamic neurons, which in turn drives downstream secretion of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThis positions Kisspeptin as a master upstream regulator of the HPG axis in preclinical research, making it a widely referenced tool compound in studies examining reproductive neuroendocrinology, puberty onset mechanisms, and fertility-related signalling pathways.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eResearch has also investigated Kisspeptin's role in mediating the negative and positive feedback effects of sex steroids on GnRH neurons, with KISS1-expressing neuronal populations in the arcuate nucleus and anteroventral periventricular nucleus proposed as key sites of steroid hormone sensing. This feedback regulation has made Kisspeptin central to research into conditions characterised by disrupted HPG axis signalling.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eBeyond reproductive biology, KISS1R expression in peripheral tissues has prompted additional investigation into Kisspeptin's potential roles in metabolic regulation and tumour suppression signalling, further broadening its research profile.\u003c\/p\u003e\n\u003ch2 class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eStability and Handling\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eKisspeptin is supplied in lyophilised (freeze-dried) form to preserve peptide integrity during storage and transport.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eStandard laboratory handling considerations include:\u003c\/p\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eRefrigerated storage following reconstitution\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eProtection from direct light exposure\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eAvoiding repeated temperature fluctuations\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eResearch Use Only\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eKisspeptin is supplied strictly for laboratory research and educational purposes. It is not approved for therapeutic use and is not intended for human consumption.\u003c\/p\u003e","brand":"Tides Lab Australia","offers":[{"title":"Default Title","offer_id":53334051094842,"sku":null,"price":59.5,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0987\/3892\/9978\/files\/Kisspeptin-5mg-web.jpg?v=1777535027","url":"https:\/\/tideslabaustralia.com.au\/products\/kisspeptin-5mg","provider":"Tides Lab Australia","version":"1.0","type":"link"}