Glutathione 1500mg – Antioxidant Research Compound | Tides Lab

Glutathione (GSH) is an endogenous tripeptide (γ-L-glutamyl-L-cysteinyl-glycine) and the most abundant intracellular antioxidant in mammalian cells. It plays a central role in cellular redox homeostasis, xenobiotic detoxification, and immune regulation, and is one of the most widely studied compounds in biochemistry and oxidative stress research.

This 1500mg lyophilised formulation is supplied at ≥99% purity and intended strictly for laboratory research purposes.

Key Features

• 1500mg lyophilised Glutathione (GSH)
• Endogenous tripeptide studied in cellular redox and antioxidant research
• Investigated across oxidative stress, detoxification and immune signalling models
• ≥99% purity
• Research use only
• Fast Australian shipping

Mechanism Overview

Glutathione functions as the primary intracellular reducing agent, maintained predominantly in its reduced (GSH) form by glutathione reductase using NADPH as a cofactor. In laboratory research models, GSH exerts its antioxidant activity through direct scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as through serving as an essential cofactor for glutathione peroxidase (GPx) enzymes, which catalyse the reduction of hydrogen peroxide and lipid hydroperoxides to non-toxic products.

The ratio of reduced GSH to oxidised glutathione (GSSG) is widely used in research as a reliable indicator of intracellular oxidative stress, making Glutathione a key reference compound in studies examining cellular redox state across a broad range of experimental models.

Beyond its antioxidant role, Glutathione is central to Phase II hepatic detoxification research, where it acts as a conjugate for electrophilic xenobiotics and reactive metabolites via glutathione S-transferase (GST) enzymes, facilitating their excretion. This detoxification mechanism has made GSH a critical compound in hepatocyte and toxicology research models.

Glutathione also plays a role in immune cell function, with research describing its involvement in T-cell proliferation, NK cell cytotoxicity, and the regulation of pro-inflammatory cytokine signalling. Antigen-presenting cells in particular require adequate intracellular GSH levels for effective antigen processing in experimental immune models.

Its involvement across such a broad range of fundamental cellular processes makes Glutathione one of the most versatile and frequently referenced compounds in biochemical and pharmacological research.

Stability and Handling

Glutathione is supplied in lyophilised (freeze-dried) form to preserve stability during storage and transport. As a thiol-containing compound, GSH is particularly susceptible to oxidation upon exposure to air, light, and elevated temperatures.

Standard laboratory handling considerations include:

• Refrigerated or frozen storage following reconstitution
• Protection from direct light and air exposure
• Use of inert atmosphere conditions where possible during handling
• Avoiding repeated temperature fluctuations

Research Use Only

Glutathione is supplied strictly for laboratory research and educational purposes. It is not approved for therapeutic use and is not intended for human consumption.